Support Articles for “The Power of Ketone Supplementation in Advancing the Quality of Your Life
-Via Steve Welch
Ketosis and General Nutrition
Therapeutic Effects (Nature Publishing Group)
- http://www.nature.com/ejcn/journal/v67/n8/pdf/ejcn2013116a.pdf
- http://www.nature.com/ejcn/journal/v67/n8/full/ejcn2013116a.html
Could this elixir hold the key to weight loss? Experts hope it’ll also treat diabetes, epilepsy, and Alzheimer’s
10 Significant Health Benefits of Low-Carb Ketogenic Diets: http://authoritynutrition.com/10-benefits-of-low-carb-ketogenic-diets/
Ketogenic diet helps weight loss, Alzheimer’s, MS and starves cancer say experts http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-alzheimer-s-ms-and-starves-cancer-say-experts
Your Brain On a Ketogenic diet (2012)
- http://martin.ankerl.com/2012/06/07/your-brain-on-a-ketogenic-diet/
- Metabolic effects of the very low carbohydrate diet: Misunderstood villain of Human Metabolism
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129159/
- Your Brain on Ketones (Psychology Today)
- https://www.psychologytoday.com/blog/evolutionary-psychiatry/201104/your-brain-ketones
- Self Experiment in Nutritional Ketosis http://floriankugler.com/blog/2013/4/8/a-self-experiment-with-nutritional-ketosis
- Ketones have therapeutic effects for diseases of substrate insufficiency or insulin resistance: “The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism”
- Great Overall Resource on Ketosis http://josepharcita.blogspot.com/2011/03/guide-to-ketosis.html
- Effects of ketogenic Mediterranean Diet with phytoextracts and low carbohydrates/high protein meals on weight, cardiovascular risk factors, body composition and diet compliance http://www.ncbi.nlm.nih.gov/pubmed/21992535
- Low carbohydrate nutrition and metabolism http://ajcn.nutrition.org/content/86/2/276.long
- Ketone Bodies: Potential Therapeutic Uses http://onlinelibrary.wiley.com/store/10.1080/152165401753311780/asset/713803796_ftp.pdf?v=1&t=idt8myef&s=e986e82c336ecca887627591430579c86b0383ca
- Thematic Review – Ketone Body Therapy: from the ketogenic diet to the oral administration of a ketone ester
- http://www.jlr.org/content/55/9/1818.full
- Ketone ester effects on metabolism and transcription
- http://www.jlr.org/content/55/10/2004.full
Navy Seals and Ketosis:
The Biochemistry of Ketogenesis and its role in weight management, neurological disease and oxidative stress
Suppression of Oxidative Stress by B-hydroxybutyrate, an endogenous histone deacetylase inhibitor
Improves Physical Performance – Ketones plus Glucose provide superior energy
Ketones in Performance cycling
- http://www.palmares.co.uk/project/ketones/
- Endurance Athletes who go against the grain become incredible fat burners (Dr. Jeff Volek study 2015)
- http://www.eurekalert.org/pub_releases/2015-11/osu-eaw111615.php
- NFL Linemen turn to ketogenic diet http://www.wsj.com/articles/nfl-linemen-turn-to-all-fat-no-carb-diet-but-science-is-unclear-1440117028
- New ketone supplement all the rage in cycling http://www.cyclingweekly.co.uk/news/latest-news/ketones-controversial-new-energy-drink-next-big-thing-cycling-151877
- Enhanced Endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet http://link.springer.com/article/10.1007/BF00392032
- Ketogenic Diet Decreased body fat without Negative effects on Strength Performance: “Ketogenic diet does not affect strength performance in elite artistic gymnasts”
- No impaired endurance performance when in ketosis: http://www.nutritionandmetabolism.com/content/1/1/2 http://eatingacademy.com/how-a-low-carb-diet-affected-my-athletic-performance
Cognitive Improvement
- Fatty acids as well as ketone bodies can be metabolized by the brain: “A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat”
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- The Effects of Beta-Hydroxybutyrate on Cognition http://www.ncbi.nlm.nih.gov/pubmed/15123336
- Dietary ketosis enhances memory in mild cognitive impairment http://www.ncbi.nlm.nih.gov/pubmed/21130529/
- Increased plasma ketone bodies resulted in a corresponding reduction in cerebral metabolic rates of glucose: http://www.ncbi.nlm.nih.gov/pubmed/23736643
- Under conditions of ketosis, glucose consumption is decreased in the cortex and cerebellum: http://www.ncbi.nlm.nih.gov/pubmed/19227486
- Gluten free ketogenic diet with MCTs reverses autism and eliminates seizures http://healthimpactnews.com/2013/gluten-free-ketogenic-diet-with-mcts-reverses-autism-and-eliminates-seizures/
Multiple Sclerosis
- Doctor Reverses MS with Ketogenic Diet. http://www.celebrityhealthfitness.com/29200/ketogenic-paleo-diet-helps-physician-reverse-multiple-sclerosis-keto-also-fights-cancer/
- Ketogenic Diet helps Alzheimer, MS, and Fights Cancer http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-alzheimer-s-ms-and-starves-cancer-say-experts
Epilepsy
- Epilepsy Foundation Web Site: Ketogenic Diet info: http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/dietary-therapies/ketogenic-diet
- Ketogenic Diet and other dietary treatments for Epilepsy http://www.ncbi.nlm.nih.gov/pubmed/22419282
- Marked Seizure Reduction after MCT Supplementation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870649/
- NY Times: Epilepsy’s Big Fat Miracle http://www.nytimes.com/2010/11/21/magazine/21Epilepsy-t.html?_r=0
- Alzheimers Disease
- A new way to produce hyperketonemia: use of a ketone ester in a case of Alzheimer’s http://www.ncbi.nlm.nih.gov/pubmed/25301680
- Ketosis Improves Cognitive Performance in Subjects with Alzheimer’s Disease: “Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial”
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- Effects of beta-hydroxybutyrate on cognition in memory impaired adults http://www.ncbi.nlm.nih.gov/pubmed/15123336
- Parkinson’s Disease:
- D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson’s disease
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193668/
- Neuroprotection for the Brain
- The Potential Neurological Benefits of Ketones (list of studies)
- http://leanmessengers.com/the-possible-neurological-benefits-of-ketosis/
- BRAIN, LIVIN’ ON KETONES – A MOLECULAR NEUROSCIENCE LOOK AT THE KETOGENIC DIET“http://www.neurorexia.com/2013/03/24/brain-livin-on-ketones-a-molecular-neuroscience-look-at-the-ketogenic-diet/
- Ketogenic Diet in Neuromuscular and Neurodegenerative diseases http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101992/
- Ketogenic Diet Provides Neuroprotective Effects Against Ischemic Stroke Neuronal Damages http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312394/
- The mitochondrial permeability transition pore provides a key to the diagnosis and treatment of traumatic brain injury http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272646/
- Ketone Bodies mediate antiseizure effects through mitochondrial permeability transition http://onlinelibrary.wiley.com/doi/10.1002/ana.24424/abstract
- Neuroprotective and disease-modifying effects of the ketogenic diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/
- Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel ( 2011 )http://www.nap.edu/openbook.php?record_id=13121&page=140
- Clinical review: Ketones and brain injury http://ccforum.com/content/15/2/219
- Beneficial Effects of Ketosis on Neurological Disorders: “Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats”
- Great information on how Ketones help a number of diseases http://www.holistichelp.net/blog/what-is-ketosis-and-is-it-dangerous/
- Cerebral metabolic adaptation and ketone metabolism after brain injury
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857668/
- Improving Insulin Insensitivity and Diabetes, Complications of Diabetes
- A low-carbohydrate, ketogenic diet to treat type 2 diabetes:
- http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-34
- Beta-Hydroxybutyrate: Much More Than a Metabolite
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414487/
- The effect of a low-carbohydrate, ketogenic diet vs a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633336/
- Treatment of diabetes and diabetic complications with a ketogenic diet http://www.ncbi.nlm.nih.gov/pubmed/23680948
- Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a Ketogenic Diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903931/
- Reversal of Diabetic Nephropathy by a ketogenic diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080383/
- Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers http://articles.mercola.com/sites/articles/archive/2014/02/02/ketogenic-diet-health-benefits.aspx?e_cid=20140202Z3_SNL_Art_1&utm_source=snl&utm_medium=email&utm_content=art1&utm_campaign=20140202Z3&et_cid=DM39012&et_rid=414716167
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- Ketones have therapeutic effects for diseases of substrate insufficiency or insulin resistance: “The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism”
Long-term ketogenic diet reduces blood glucose: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
Improving Cellular Health and Longevity, Anti-aging
- Ketogenic Diet Could Delay the Effects of Aging http://www.medindia.net/news/ketogenic-diet-could-delay-the-effects-of-aging-111146-1.htm
- Scientists see a Ketogenic Diet for Aging and Longevity http://longevitycentresofamerica.wordpress.com/2012/12/09/scientists-see-potential-in-ketogenic-diet-for-aging-longevity/
- Gladstone Scientists Discover Novel Mechanism by Which Calorie Restriction Influences Longevity
- http://gladstone.org/about-us/press-releases/gladstone-scientists-discover-novel-mechanism-which-calorie-restriction
- Ketosis cleans our cells http://www.proteinpower.com/drmike/ketones-and-ketosis/ketosis-cleans-our-cells/
- Beta Hydroxybutyrate extends lifespan in C elegans. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169858/
Weight Loss – Fat loss without muscle loss
- Mouse study identifies KE as a potential antiobesity supplement: “Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet KE as a potential antiobesity supplement”
- Subjective Appetite Reduced on Ketogenic Diet: “Ketosis and appetite-mediating nutrients and hormones after weight loss”
- Medium chain fatty acid acts in the liver to produce a signal that inhibits feeding in rats: “Caprylic acid infusion acts in the liver to decrease food intake in rats”
- Ketogenic Diet Decreased body fat without Negative effects on Strength Performance: “Ketogenic diet does not affect strength performance in elite artistic gymnasts”
- Summary of the known central effects of BHBA: “Role of beta-hydroxybutyric acid in the central regulation of energy balance”
- Long-term ketogenic diet significantly reduced the body weight and body mass index of the patients: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
Cancer Inhibiting – Cancer cells can’t live using ketones as a fuel source
- http://www.naturalhealth365.com/stop_cancer/ketogenic_diet.html
- http://articles.mercola.com/sites/articles/archive/2013/03/10/ketogenic-diet.aspx
- Open access to Dr. D’Agostino’s recent study on Cancer: “The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer”
Ketogenic Diet and Cancer Benefits
- http://articles.mercola.com/sites/articles/archive/2013/06/16/ketogenic-diet-benefits.aspx
- Ketones and cancer: “What is the Origin of Cancer?”
- Ketogenic Diet for Cancer – Clinical Trial http://coconutketones.blogspot.com/2013/01/ketogenic-diet-for-cancer-clinical-trial.html
Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. http://www.ncbi.nlm.nih.gov/pubmed/7790697